ISSN 1662-4009 (online)

ey0016.11-14 | Treatment of Severe Obesity: Next Steps | ESPEYB16

11.14. Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review

L van Iersel , KE Brokke , RAH Adan , LCM Bulthuis , ELT van den Akker , HM van Santen

To read the full abstract: Endocr Rev. 2019;40(1):193–235This paper combines a comprehensive review of current knowledge on pathophysiologic mechanisms contributing to hypothalamic obesity in craniopharyngioma patients with a systematic literature review of intervention studies for weight management in this patient population. Findings of both reviews are merged into evidence-...

ey0020.6-9 | New Concerns | ESPEYB20

6.9. Leukocyte telomere length in children with congenital adrenal hyperplasia

C Raftopoulou , O Abawi , G Sommer , M Binou , G Paltoglou , CE Fluck , ELT van den Akker , E Charmandari

Brief summary: This prospective observational cohort study determined leukocyte telomere length (LTL) in 76 patients with genetically confirmed CAH (83% classic CAH). LTL was shorter in patients with classic vs nonclassic CAH, in overtreated than in optimally treated patients, and patients receiving prednisolone compared with hydrocortisone.Telomeres are tandem repeats of a noncoding hexameric nucleotide sequence (5′-TTAGGG-3′) located at the...